There are a few factors to consider when purchasing a gaming mouse for large hands. The first is the size of the mouse. Some mice are too small for large hands, and can be uncomfortable to use. The second is the grip. Some mice have a claw grip that can be uncomfortable for large hands. The third is the buttons. Some mice have small buttons that can be difficult to press for large hands.
The best gaming mouse for large hands is the Logitech G502. It is a large mouse with a comfortable grip and large buttons.